Bisoren Plus (Bisoprolol Fumarate 2.50mg + Hydrochlorothiazide 6.25mg) is prescribed for the treatment of high blood pressure (hypertension).
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Bisoren Plus contains a combination of Bisoprolol Fumarate (a β1-selective beta-blocker) and Hydrochlorothiazide (a thiazide diuretic). Used together, they offer a stronger blood pressure-lowering effect than when used alone. Hydrochlorothiazide 6.25 mg enhances the antihypertensive effect of Bisoprolol, while also reducing the risk of low potassium levels compared to a higher dose of Hydrochlorothiazide (25 mg).
Bisoprolol selectively blocks β1-adrenergic receptors (mainly in the heart) without intrinsic sympathomimetic activity.
Hydrochlorothiazide increases sodium and chloride excretion by affecting electrolyte reabsorption in the kidneys.
Beta-blocker overdose symptoms:
Thiazide overdose symptoms:
Most patients tolerate Bisoren Plus well, but side effects may include:
Pregnancy: Category C. It should only be used if the benefit outweighs the risk.
Breastfeeding: Not recommended. Thiazides pass into breast milk, and bisoprolol may be present in small amounts. A decision should be made whether to stop breastfeeding or discontinue the medication.
Store below 30°C, away from moisture and light. Keep out of reach of children.
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