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Bisoren Plus 2.5mg +6.25mg Tablet 1 Strip
Bisoren Plus (Bisoprolol Fumarate 2.50mg + Hydrochlorothiazide 6.25mg) is prescribed for the treatment of high blood pressure (hypertension).
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✅ Description:
Bisoren Plus contains a combination of Bisoprolol Fumarate (a β1-selective beta-blocker) and Hydrochlorothiazide (a thiazide diuretic). Used together, they offer a stronger blood pressure-lowering effect than when used alone. Hydrochlorothiazide 6.25 mg enhances the antihypertensive effect of Bisoprolol, while also reducing the risk of low potassium levels compared to a higher dose of Hydrochlorothiazide (25 mg).
Bisoprolol selectively blocks β1-adrenergic receptors (mainly in the heart) without intrinsic sympathomimetic activity.
Hydrochlorothiazide increases sodium and chloride excretion by affecting electrolyte reabsorption in the kidneys.
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✔️ Overdose Information
Beta-blocker overdose symptoms:
- Slow heart rate, low blood pressure, fatigue, confusion, seizures, breathing difficulty, heart failure, and low blood sugar.
Thiazide overdose symptoms:
- Fluid and electrolyte loss, dizziness, weakness, nausea, changes in urine output, and electrolyte abnormalities like low potassium, sodium, or chloride.
✔️ Dosage & Administration
- Bisoprolol is typically effective at daily doses of 2.5–40 mg.
- Hydrochlorothiazide works well at daily doses of 12.5–50 mg.
In combination therapy, Bisoren Plus is available with 2.5–20 mg of Bisoprolol and 6.25–25 mg of Hydrochlorothiazide. - Initial Dose: Start with one tablet of 2.5 mg/6.25 mg once daily.
- Titration: Dosage can be adjusted every 14 days, up to a maximum of 20 mg/12.5 mg once daily, as needed.
- Replacement Therapy: Can replace individual drugs if the patient is already stabilized on them.
- Clinical Use: Suitable for patients who are not achieving control with Bisoprolol alone or those experiencing potassium loss with high-dose Hydrochlorothiazide.
✔️ Side Effects
Most patients tolerate Bisoren Plus well, but side effects may include:
- Tiredness, dizziness, slow heart rate (bradycardia), irregular heartbeat
- Chest pain, cold hands and feet, low blood pressure (especially when standing)
- Digestive issues (nausea, constipation, diarrhea, indigestion)
- Respiratory symptoms (runny nose, sore throat)
✔️ Drug Interactions
- It may enhance the effects of other blood pressure-lowering medications.
- Avoid combining with other beta-blockers.
- Use caution with catecholamine-depleting agents (e.g., reserpine, guanethidine) due to the risk of excessive sympathetic suppression.
- If also on clonidine, stop Bisoren Plus a few days before discontinuing clonidine.
- Take care when used with cardiac depressants like verapamil, diltiazem, disopyramide, or digoxin, as they may increase the risk of slow heart rate (bradycardia) or heart block.
✔️ Do not use in patients with:
- Cardiogenic shock
- Decompensated heart failure
- Second or third-degree AV block
- Severe bradycardia
- Anuria (no urine output)
- Allergy to any component of the drug or to sulfonamides
✔️ Use in Pregnancy and Lactation
Pregnancy: Category C. It should only be used if the benefit outweighs the risk.
Breastfeeding: Not recommended. Thiazides pass into breast milk, and bisoprolol may be present in small amounts. A decision should be made whether to stop breastfeeding or discontinue the medication.
✔️ Precautions & Warnings
- Thiazides can cause hyperuricemia or gout.
- Watch for signs of fluid or electrolyte imbalance: dry mouth, thirst, weakness, drowsiness, cramps, low blood pressure, or gastrointestinal upset.
- Low potassium (hypokalemia) may occur.
- Discontinue the medication gradually over 2 weeks to avoid adverse reactions.
- Monitor patients closely during withdrawal.
✔️ Storage Condition
Store below 30°C, away from moisture and light. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
